Pharmacology :  Subject codes - BP404T, BP503T and BP602T  (Syllabus designed by PCI for B. Pharm)

BP404T - PHARMACOLOGY-I (Theory) (4th Sem)

 

UNIT-I

 

1. General Pharmacology

a. Introduction to Pharmacology- Definition, historical landmarks and scope of pharmacology, nature and source of drugs, essential drugs concept and routes of drug administration, Agonists, antagonists ( competitive and non competitive), spare receptors, addiction, tolerance, dependence, tachyphylaxis, idiosyncrasy, allergy.

b. Pharmacokinetics- Membrane transport, absorption, distribution, metabolism and excretion of drugs . Enzyme induction, enzyme inhibition, kinetics of elimination

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UNIT-II

General Pharmacology

a. Pharmacodynamics- Principles and mechanisms of drug action. Receptor theories and classification of receptors, regulation of receptors. drug receptors interactions signal transduction mechanisms, G-protein–coupled receptors, ion channel receptor, transmembrane enzyme linked receptors, transmembrane JAK-STAT binding receptor and receptors that regulate transcription factors, dose response relationship, therapeutic index, combined effects of drugs and factors modifying drug action.

b. Adverse drug reactions.

c. Drug interactions (pharmacokinetic and pharmacodynamic)

d. Drug discovery and clinical evaluation of new drugs -Drug discovery phase, preclinical evaluation phase, clinical trial phase, phases of clinical trials and

pharmacovigilance.

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UNIT-III

2. Pharmacology of drugs acting on peripheral nervous system

a. Organization and function of ANS.

b.Neurohumoral transmission,co-transmission and classification of neurotransmitters.

c. Parasympathomimetics, Parasympatholytics, Sympathomimetics, sympatholytics.

d. Neuromuscular blocking agents and skeletal muscle relaxants (peripheral).

e. Local anesthetic agents.

f. Drugs used in myasthenia gravis and glaucoma

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UNIT-IV

3. Pharmacology of drugs acting on central nervous system

a. Neurohumoral transmission in the C.N.S.special emphasis on importance of various neurotransmitters like with GABA, Glutamate, Glycine, serotonin, dopamine.

b. General anesthetics and pre-anesthetics.

c. Sedatives, hypnotics and centrally acting muscle relaxants.

d. Anti-epileptics

e. Alcohols and disulfiram

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UNIT-V

3. Pharmacology of drugs acting on central nervous system

a. Psychopharmacological agents: Antipsychotics, antidepressants, anti-anxiety agents, anti-manics and hallucinogens.

b. Drugs used in Parkinsons disease and Alzheimer’s disease.

c. CNS stimulants and nootropics.

d. Opioid analgesics and antagonists

e. Drug addiction, drug abuse, tolerance and dependence.

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BP503T-PHARMACOLOGY-II (Theory) (5th Sem)

 

UNIT-I

 

1. Pharmacology of drugs acting on cardio vascular system

a. Introduction to hemodynamic and electrophysiology of heart.

b. Drugs used in congestive heart failure

c. Anti-hypertensive drugs.

d. Anti-anginal drugs.

e. Anti-arrhythmic drugs.

f. Anti-hyperlipidemic drugs.

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UNIT-II

1. Pharmacology of drugs acting on cardio vascular system

a. Drug used in the therapy of shock.

b. Hematinics, coagulants and anticoagulants.

c. Fibrinolytics and anti-platelet drugs

d. Plasma volume expanders

2. Pharmacology of drugs acting on urinary system

a. Diuretics

b. Anti-diuretics.

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UNIT-III

3. Autocoids and related drugs

a. Introduction to autacoids and classification

b. Histamine, 5-HT and their antagonists.

c. Prostaglandins, Thromboxanes and Leukotrienes.

d. Angiotensin, Bradykinin and Substance P.

e. Non-steroidal anti-inflammatory agents

f. Anti-gout drugs

g. Antirheumatic drugs

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UNIT-IV

5. Pharmacology of drugs acting on endocrine system

a. Basic concepts in endocrine pharmacology.

b. Anterior Pituitary hormones- analogues and their inhibitors.

c. Thyroid hormones- analogues and their inhibitors.

d. Hormones regulating plasma calcium level- Parathormone, Calcitonin and

Vitamin-D.

d. Insulin, Oral Hypoglycemic agents and glucagon.

e. ACTH and corticosteroids.

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UNIT-V

5. Pharmacology of drugs acting on endocrine system

a. Androgens and Anabolic steroids.

b. Estrogens, progesterone and oral contraceptives.

c. Drugs acting on the uterus.

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BP602 T. PHARMACOLOGY-III (Theory) (6th Sem)

 

UNIT-I

1. Pharmacology of drugs acting on Respiratory system

a. Anti -asthmatic drugs

b. Drugs used in the management of COPD

c. Expectorants and antitussives

d. Nasal decongestants

e. Respiratory stimulants

2. Pharmacology of drugs acting on the Gastrointestinal Tract

a. Antiulcer agents.

b. Drugs for constipation and diarrhoea.

c. Appetite stimulants and suppressants.

d. Digestants and carminatives.

e. Emetics and anti-emetics.

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UNIT-II

3. Chemotherapy

a. General principles of chemotherapy.

b. Sulfonamides and cotrimoxazole.

c. Antibiotics- Penicillins, cephalosporins, chloramphenicol, macrolides, quinolones and fluoroquinolins, tetracycline and aminoglycosides

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UNIT-III

3. Chemotherapy

a. Antitubercular agents

b. Antileprotic agents

c. Antifungal agents

d. Antiviral drugs

e.Anthelmintics

f. Antimalarial drugs

g. Antiamoebic agents

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UNIT-IV

3. Chemotherapy

l. Urinary tract infections and sexually transmitted diseases.

m. Chemotherapy of malignancy.

4. Immunopharmacology

a. Immunostimulants

b. Immunosuppressant

Protein drugs, monoclonal antibodies, target drugs to antigen, biosimilars

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UNIT-V

5. Principles of toxicology

a. Definition and basic knowledge of acute, subacute and chronic toxicity.

b. Definition and basic knowledge of genotoxicity, carcinogenicity, teratogenicity and mutagenicity

c. General principles of treatment of poisoning

d. Clinical symptoms and management of barbiturates, morphine, organophosphosphorus compound and lead, mercury and arsenic poisoning.

6. Chronopharmacology

a. Definition of rhythm and cycles.

b. Biological clock and their significance leading to chronotherapy.

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